We are constantly told that ‘nano’ science and technology are going to revolutionise our lives – but what does this really mean? This paper aims to introduce and engage its audience in the experiment that is nanoscale sciences and technologies, particularly from the perspectives of consumer and environmental protection and occupational health and safety. By concluding with recommendations for policy, it aims to create a setting in which there can be an open debate over our collective involvement in this experiment and a broad-based public negotiation about appropriate controls.